Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.47 |
| ▸ | MERTK | Q12866 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7817712 | 0.99 | LMNA (0.56) | LMNAMAPK1HPGDKDM4ETSHR | |
| SCHEMBL7818494 | 0.85 | LMNA (0.39) | LMNAMAPK1HPGDKDM4ETSHR | |
| Hydrochloric Acid SCHEMBL7818505 | 0.85 | LMNA (0.41) | LMNAMAPK1HPGDKDM4ETSHR | |
| SCHEMBL7818149 | 0.85 | KDM1A (0.40) | LMNAMAPK1HPGDKDM4ETSHR | |
| Revaprazan SCHEMBL29388090 | 0.84 | MEN1 (0.40) | LMNAMAPK1HPGDKDM4ETSHR | |
| Revaprazan SCHEMBL6990999 | 0.84 | MEN1 (0.40) | LMNAMAPK1HPGDKDM4ETSHR | |
| Revaprazan SCHEMBL2194461 | 0.84 | MEN1 (0.40) | LMNAMAPK1HPGDKDM4ETSHR | |
| Revaprazan SCHEMBL6993033 | 0.84 | MEN1 (0.40) | LMNAMAPK1HPGDKDM4ETSHR | |
| Hydrochloric Acid SCHEMBL7818515 | 0.84 | LMNA (0.40) | LMNAMAPK1HPGDKDM4ETSHR | |
| Revaprazan SCHEMBL6994677 | 0.84 | LMNA (0.40) | LMNAMAPK1HPGDKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677049-B1 | QUINAZOLINE DERIVATIVES | YUHAN CORP LTD (KR) | 2001-07-25 | — | — | EP | claimed |
| EP-0677049-B1 | QUINAZOLINE DERIVATIVES | YUHAN CORP LTD (KR) | 2001-07-25 | — | — | EP | disclosed |
| US-5686458-A | Quinazoline deriviates for treating peptic ulcer | YUHAN CORPORATION (KR) | 1997-11-11 | — | — | US | disclosed |
| EP-0677049-A1 | QUINAZOLINE DERIVATIVES | YUHAN CORPORATION, LTD. (KR) | 1995-10-18 | — | — | EP | disclosed |
| WO-1994014795-A1 | QUINAZOLINE DERIVATIVES | YUHAN CORPORATION (KR) | 1994-07-07 | — | — | WO | disclosed |