Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.34 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | MYB | P10242 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7128002 | 0.92 | MAPT (0.36) | MAPTALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL27501457 | 0.87 | HIF1A (0.34) | MAPTALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL2400659 | 0.85 | KDM4E (0.38) | MAPTALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL5097862 | 0.83 | KDM4E (0.40) | MAPTALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL12316024 | 0.82 | CHRM5 (0.37) | MAPTALDH1A1KDM4EGAAHTT | |
| SCHEMBL7821439 | 0.80 | NPC1 (0.37) | MAPTALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL6901395 | 0.79 | KDM4E (0.33) | MAPTALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL3926851 | 0.79 | DPP4 (0.36) | MAPTALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL2599683 | 0.79 | ALDH1A1 (0.38) | MAPTALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL7122482 | 0.78 | DPP4 (0.35) | MAPTALDH1A1KDM4ENPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0704067-B1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG IND OHIO INC (US) | 2001-08-01 | — | — | EP | disclosed |
| EP-0704067-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1996-04-03 | — | — | EP | disclosed |
| EP-0704067-A4 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES INC (US) | 1996-02-02 | — | — | EP | disclosed |
| US-5458815-A | Photochromic naphthopyran compounds | TRANSITIONS OPTICAL, INC. (US) | 1995-10-17 | — | — | US | disclosed |
| US-5384077-A | Naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 1995-01-24 | — | — | US | disclosed |
| WO-1995000866-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1995-01-05 | — | — | WO | disclosed |