Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | S100A4 | P26447 | 4/20 | 0.43 |
| ▸ | CDC25B | P30305 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7809332 | 0.90 | TDP2 (0.45) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL10806544 | 0.84 | MAPK13 (0.62) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL7816711 | 0.82 | TOP2A (0.51) | S100A4CDC25BTDP1TOP2AIDO1 | |
| SCHEMBL7812072 | 0.77 | MAPK13 (0.44) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL7820210 | 0.76 | KAT2B (0.45) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL7819985 | 0.72 | TOP2A (0.51) | S100A4CDC25BTDP1TDP2NSD2 | |
| SCHEMBL10799732 | 0.72 | MAPK13 (0.38) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL7808475 | 0.67 | TOP2A (0.47) | TOP2AIDO1 | |
| SCHEMBL7809337 | 0.67 | TOP2A (0.49) | S100A4MEN1THRBBLMKMT2A | |
| SCHEMBL7816371 | 0.67 | KAT2B (0.45) | S100A4TOP2AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |
| EP-0750619-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1997-01-02 | — | — | EP | disclosed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |