Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 12/20 | 0.51 |
| ▸ | IDO1 | P14902 | 3/20 | 0.39 |
| ▸ | TDO2 | P48775 | 2/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816711 | 0.92 | TOP2A (0.51) | TOP2AIDO1TDO2TDP1S100A4 | |
| SCHEMBL7816428 | 0.84 | TOP2A (0.45) | TOP2AIDO1TDO2 | |
| SCHEMBL7809332 | 0.82 | TDP2 (0.45) | TOP2AIDO1TDP2NSD2ABL1 | |
| SCHEMBL7817109 | 0.81 | TOP2A (0.44) | TOP2AIDO1TDO2S100A4 | |
| SCHEMBL7804662 | 0.81 | TOP2A (0.48) | TOP2ATDP2TDP1CDC25B | |
| SCHEMBL7819270 | 0.77 | TOP2A (0.43) | TOP2AIDO1TDO2 | |
| SCHEMBL10801094 | 0.77 | TOP2A (0.46) | TOP2A | |
| SCHEMBL10799708 | 0.76 | POLB (0.55) | TOP2ANSD2 | |
| SCHEMBL7808475 | 0.76 | TOP2A (0.47) | TOP2AIDO1TDO2 | |
| SCHEMBL7812061 | 0.75 | TOP2A (0.45) | TOP2ATDP2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |