Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818830 | 0.91 | HTR7 (0.46) | HTR7HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7817734 | 0.89 | HTR7 (0.44) | HTR7HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7816875 | 0.84 | HTR7 (0.38) | HTR7HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7816733 | 0.84 | HTR7 (0.48) | HTR7HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7819444 | 0.81 | HTR7 (0.42) | HTR7HTR1ADRD2SIGMAR1DRD4 | |
| SCHEMBL7824391 | 0.81 | HTR7 (0.52) | HTR7HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7809525 | 0.81 | DRD4 (0.42) | HTR7TMEM97SIGMAR1DRD4 | |
| SCHEMBL6997493 | 0.80 | HTR7 (0.48) | HTR7HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7817649 | 0.78 | HTR1A (0.48) | HTR7HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7817007 | 0.77 | HTR7 (0.47) | HTR7HTR1ADRD2HTR2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294677-B1 | HAS SEROTONIN-2-RECEPTER ANTAGONISTIC ACTION AND USEFUL AS A DRUG FOR PREVENTING OR TREATING ISCHEMIC HEART DISEASES, CEREBROVASCULAR DISTURBANCE, AND PERIPHERAL CIRCULATORY DISTURBANCE, WITH MINIMAL TOXIC OR SIDE EFFECTS | SUNTORY LIMITED (JP) | 2001-09-25 | — | — | US | disclosed |
| EP-0749971-B1 | Thiopyran derivatives | SUNTORY LTD (JP) | 2001-03-14 | — | — | EP | disclosed |
| US-6100265-A | BENZOTHIOPYRAN AND THIENOTHIOPYRAN DERIVATIVES; SEROTONIN-2 BLOCKING ACTION; TREATMENT OF CIRCULATORY DISEASES IN GENERAL SUCH AS HYPERTENSION, ISCHEMIC HEART DISEASE, CEREBROVASCULAR DISTURBANCE, AND PERIPHERAL CIRCULATORY DISTURBANCE | SUNTORY LIMITED (JP) | 2000-08-08 | — | — | US | disclosed |
| US-5977111-A | Thiopyran derivatives | SUNTORY LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| EP-0749971-A1 | Thiopyran derivatives | SUNTORY LIMITED (JP) | 1996-12-27 | — | — | EP | disclosed |