Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78783 | 0.86 | PDK1 (0.39) | PDK1PDK2PDK3PDK4PSEN1 | |
| SCHEMBL8701756 | 0.83 | PSEN1 (0.41) | PDK1PDK2PDK3PDK4PSEN1 | |
| SCHEMBL8701755 | 0.83 | PSEN1 (0.41) | PDK1PDK2PDK3PDK4PSEN1 | |
| SCHEMBL30781570 | 0.82 | POLB (0.44) | PDK1PDK2PDK3PDK4AGTR2 | |
| SCHEMBL29560191 | 0.81 | SMN1; SMN2 (0.45) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL78361 | 0.81 | PARP1 (0.43) | PDK1PDK2PDK3PDK4PARP1 | |
| SCHEMBL1058639 | 0.81 | POLB (0.49) | PDK1PDK2PDK3PDK4PSEN1 | |
| SCHEMBL15341340 | 0.81 | PDK1 (0.45) | PDK1PDK2PDK3PDK4AGTR2 | |
| SCHEMBL1058641 | 0.81 | POLB (0.49) | PDK1PDK2PDK3PDK4PSEN1 | |
| SCHEMBL8699830 | 0.81 | POLB (0.49) | PDK1PDK2PDK3PDK4PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |