Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8701755 | 0.90 | PSEN1 (0.41) | PDK1PDK2PDK3PDK4FKBP1A | |
| SCHEMBL8701756 | 0.90 | PSEN1 (0.41) | PDK1PDK2PDK3PDK4FKBP1A | |
| SCHEMBL29560191 | 0.86 | SMN1; SMN2 (0.45) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL6475398 | 0.84 | PREP (0.49) | — | |
| SCHEMBL6475389 | 0.84 | PREP (0.49) | — | |
| SCHEMBL6484219 | 0.84 | PREP (0.49) | — | |
| SCHEMBL29185150 | 0.84 | PSEN1 (0.40) | — | |
| SCHEMBL30694003 | 0.84 | PSEN1 (0.40) | — | |
| SCHEMBL3637452 | 0.83 | FKBP1A (0.48) | FKBP1A | |
| SCHEMBL7576828 | 0.82 | PDK1 (0.40) | PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |