Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 4/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.35 |
| ▸ | WNT3A | P56704 | 4/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7611777 | 0.83 | CTSK (0.35) | CTSLCTSBCTSSCTSKCTNNB1 | |
| SCHEMBL7813767 | 0.79 | CTSL (0.43) | CTSLCTSBCTSSCTSKCTNNB1 | |
| SCHEMBL7812729 | 0.75 | CYP3A4 (0.36) | CTSLCTSBCTSSCTSKSLC6A9 | |
| SCHEMBL7611780 | 0.75 | CTSL (0.46) | CTSLCTSBCTSSCTSKCTNNB1 | |
| SCHEMBL7609927 | 0.72 | CTSL (0.36) | CTSLCTSBCTSSCTSKSLC6A9 | |
| SCHEMBL7815927 | 0.72 | CYP3A4 (0.35) | CTSLCTSBCTSSCTSKMEN1 | |
| SCHEMBL7617860 | 0.72 | CYP3A4 (0.36) | CTSLCTSBCTSSCTSKALDH1A1 | |
| SCHEMBL6623377 | 0.67 | CTSL (0.47) | CTSLCTSBCTSSCTSKMEN1 | |
| SCHEMBL7812726 | 0.67 | CYP3A4 (0.35) | CTSLCTSBCTSSCTSKSLC6A9 | |
| SCHEMBL7618533 | 0.67 | GBA1 (0.38) | CTSLCTSBCTSSCTSKSLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068304-A4 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORP (US) | 2001-05-09 | — | — | EP | disclosed |
| EP-1068304-A1 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999053039-A1 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-21 | — | — | WO | disclosed |