Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 12/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8492206 | 0.79 | TLR9 (0.39) | MTORHIF1AKDM4EALDH1A1HPGD | |
| SCHEMBL7825968 | 0.78 | WHR1 (0.46) | MTORRAB9AHIF1AKDM4EALDH1A1 | |
| SCHEMBL7820197 | 0.78 | PDE4A (0.48) | MTORKDM4EALDH1A1HPGDPDE4D | |
| SCHEMBL8138601 | 0.77 | WHR1 (0.42) | HIF1AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL7819852 | 0.75 | WHR1 (0.48) | MTORRAB9AHIF1AKDM4EALDH1A1 | |
| SCHEMBL3524604 | 0.74 | ALDH1A1 (0.46) | QPCTCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8637407 | 0.73 | PDE4A (0.41) | RAB9AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7820762 | 0.73 | SLC10A2 (0.52) | QPCTTP53ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL8884921 | 0.71 | KDM4E (0.48) | HIF1AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL7809984 | 0.71 | QPCT (0.44) | QPCTTP53KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608870-B1 | Quinoline or quinazoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-09-05 | — | — | EP | disclosed |
| EP-0634169-B1 | Quinoline or quinazoline derivatives and their use in the manufacture of a medicament for the treatment of osteoporosis | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-01-05 | — | — | EP | disclosed |
| US-5932592-A | ETHYL 4-(3,4-DIMETHOXYPHENYL)-6,7-DIMETHOXY-2-(1,2,4-TRIAZOLE-1-YLME THYL)QUINOLINE-3-CARBOXYLATE; ANTIINFLAMMATORY AND ANTIARTHRITIC AGENT | TAKEDA CHEMICAL IND., LTD. (JP) | 1999-08-03 | — | — | US | disclosed |
| US-5852039-A | Pharmaceutical composition containing quinoline or quinazoline derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-12-22 | — | — | US | disclosed |
| US-5770602-A | REACTING QUIONOZOLINE OR QUINOLINE DERIVATIVES CONTAINING LEAVING GROUPS WITH NITROGEN CONTAINING UNSATURATED CYCLIC GROUP WHICH MAY BE SUBSTITUTED OR UNSUBSTITUTED; ANTIARTHRITIC AGENT | TAKEDA CHEMICAL INDUSTRIES (JP) | 1998-06-23 | — | — | US | disclosed |
| US-5719157-A | OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-17 | — | — | US | disclosed |
| US-5436247-A | Antiinflammatory agents or antiarthritic agents | TAKEDA CHEMICAL INDUSTRIES (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0634169-A1 | Pharmaceutical composition containing quinoline or quinazoline derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-01-18 | — | — | EP | disclosed |
| EP-0608870-A1 | Quinoline or quinazoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-08-03 | — | — | EP | disclosed |