Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | DUT | P33316 | 1/20 | 0.32 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3155510 | 0.88 | KDM4E (0.58) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL7813547 | 0.82 | KDM4E (0.66) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL7813412 | 0.80 | KDM4E (0.48) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL7814812 | 0.80 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL3158156 | 0.80 | KDM4E (0.69) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL7981421 | 0.78 | KDM4E (0.47) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL9873437 | 0.78 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL7967624 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL14163777 | 0.75 | KDM4E (0.69) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL3155583 | 0.74 | KDM4E (0.67) | KDM4EALDH1A1HPGDADRA1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0352953-B1 | Process for the preparation of purine derivatives | BEECHAM GROUP PLC (GB) | 2001-01-03 | — | — | EP | disclosed |
| US-5017701-A | Process for the preparation of purine derivatives | BEECHAM GROUP, P.L.C. (GB) | 1991-05-21 | — | — | US | disclosed |
| EP-0352953-A2 | Process for the preparation of purine derivatives | BEECHAM GROUP PLC (GB) | 1990-01-31 | — | — | EP | disclosed |