Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816726 | 0.86 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4EADRA1AHSD17B10 | |
| SCHEMBL7813412 | 0.81 | KDM4E (0.48) | ALDH1A1HPGDKDM4EADRA1AHSD17B10 | |
| SCHEMBL9873437 | 0.80 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4EADRA1AHSD17B10 | |
| SCHEMBL7819795 | 0.80 | KDM4E (0.57) | ALDH1A1HPGDKDM4EADRA1AHSD17B10 | |
| SCHEMBL3155510 | 0.79 | KDM4E (0.58) | ALDH1A1HPGDKDM4EADRA1AHSD17B10 | |
| SCHEMBL7814637 | 0.78 | CYP1A2 (0.59) | ALDH1A1HPGDKDM4EADRA1AHSD17B10 | |
| SCHEMBL6317462 | 0.75 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM4EADRA1AHSD17B10 | |
| SCHEMBL3158156 | 0.71 | KDM4E (0.69) | ALDH1A1HPGDKDM4EADRA1AHSD17B10 | |
| SCHEMBL7981421 | 0.70 | KDM4E (0.47) | ALDH1A1HPGDKDM4EADRA1AHSD17B10 | |
| SCHEMBL14163777 | 0.69 | KDM4E (0.69) | ALDH1A1HPGDKDM4EADRA1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0352953-B1 | Process for the preparation of purine derivatives | BEECHAM GROUP PLC (GB) | 2001-01-03 | — | — | EP | disclosed |
| US-5017701-A | Process for the preparation of purine derivatives | BEECHAM GROUP, P.L.C. (GB) | 1991-05-21 | — | — | US | disclosed |
| EP-0352953-A2 | Process for the preparation of purine derivatives | BEECHAM GROUP PLC (GB) | 1990-01-31 | — | — | EP | disclosed |