SCHEMBL7820178

SCHEMBL7820178

N#Cc1ccccc1C(=O)CN(C=O)C=O

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.37
MEN1 O00255 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ALDH1A1 P00352 3/20 0.36
KDM4E B2RXH2 2/20 0.36
NPC1 O15118 1/20 0.36
PPIA P62937 1/20 0.36
GAA P10253 3/20 0.36
TSHR P16473 2/20 0.36
OPRK1 P41145 1/20 0.36
POLB P06746 2/20 0.35
MAPT P10636 1/20 0.35
LMNA P02545 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2558412 0.78 PPIA (0.38) ALDH1A1KDM4ENPC1PPIAGAA
SCHEMBL7821787 0.76 ALDH1A1 (0.52) KMT2ATDP1ALDH1A1KDM4ETSHR
SCHEMBL8239082 0.74 TSHR (0.52) ALDH1A1NPC1PPIAGAATSHR
SCHEMBL27576279 0.74 MAPT (0.42) ALDH1A1KDM4ENPC1PPIAGAA
SCHEMBL29777919 0.74 TSHR (0.52) ALDH1A1NPC1PPIAGAATSHR
SCHEMBL392810 0.74 PTPN1 (0.50) KMT2AMEN1TDP1KDM4EPPIA
SCHEMBL28662371 0.71 TSHR (0.39) ALDH1A1KDM4ENPC1PPIAGAA
SCHEMBL31575826 0.71 PPIA (0.43) KMT2AMEN1ALDH1A1KDM4EPPIA
SCHEMBL2913776 0.70 ALDH1A1 (0.45) ALDH1A1KDM4EPPIAGAATSHR
SCHEMBL31000747 0.70 PPIA (0.45) ALDH1A1KDM4EPPIAGAATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0880522-B1 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES AMPA AND NMDA RECEPTORS ANTAGONISTS, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME AVENTIS PHARMA SA (FR) 2001-09-19 EP disclosed
US-6100264-A 5H, 10H-imidazo [1,2-A] indeno [1,2-E] pyrazin-4-one derivatives, their preparation, their intermediates and medicaments containing them RHONE-POULENC RORER, S.A. (FR) 2000-08-08 US disclosed
US-5990108-A USEFUL AS ANTAGONISTS OF THE ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (AMPA) RECEPTOR, ALSO KNOWN AS THE QUISQUALATE RECEPTOR, AND AS ANTAGONISTS OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR RHONE POULENC RORER S.A. (FR) 1999-11-23 US disclosed
EP-0880522-A1 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME Aventis Pharma S.A. (FR) 1998-12-02 EP disclosed
WO-1997025328-A1 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME RHONE-POULENC RORER S.A. (FR) 1997-07-17 WO disclosed