Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 3/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835702 | 0.89 | KCNN3 (0.39) | KDM5AKDM5BKDM4CKCNN3PRKAB2 | |
| SCHEMBL7821016 | 0.88 | KDM5A (0.41) | KDM5AKDM5BKDM4CPRKAB2PRKAG1 | |
| SCHEMBL7830500 | 0.84 | KDM5A (0.39) | KDM5AKDM5BKDM4CKCNN3PRKAB2 | |
| SCHEMBL7834918 | 0.84 | LOXL2 (0.38) | KCNN3PDE10AKCNN1KCNN2 | |
| SCHEMBL7821004 | 0.80 | KDM5A (0.38) | KDM5AKDM5BKDM4CKCNN3PRKAB2 | |
| SCHEMBL7831474 | 0.80 | PDE10A (0.35) | KCNN3PDE10AADORA3LMNAHTT | |
| SCHEMBL7832013 | 0.79 | KDM5A (0.39) | KDM5AKDM5BKDM4CPRKAB2PRKAG1 | |
| SCHEMBL7833319 | 0.78 | LOXL2 (0.46) | KCNN3PDE10ALMNAMAPTKCNN1 | |
| SCHEMBL7830382 | 0.78 | KDM5A (0.40) | KDM5AKDM5BKDM4CKCNN3PRKAB2 | |
| SCHEMBL7836134 | 0.77 | PDE10A (0.53) | KCNN3PRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820997-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5985882-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0820997-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-28 | — | — | EP | disclosed |