Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 18/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 18/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 18/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 18/20 | 0.48 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.41 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.41 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7829738 | 0.84 | PDK1 (0.46) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL7833074 | 0.81 | PDK1 (0.56) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7821393 | 0.80 | ALDH1A1 (0.49) | — | |
| SCHEMBL7821009 | 0.77 | PDK1 (0.48) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL7835045 | 0.77 | PDK1 (0.48) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7833658 | 0.75 | PDK1 (0.46) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL27574618 | 0.67 | PDK1 (0.73) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7829272 | 0.67 | PDK1 (0.46) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL6356221 | 0.67 | PDK1 (0.77) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL6350100 | 0.66 | PDK1 (1.00) | PDK1PDK2PDK3PDK4ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798288-B1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2001-05-16 | — | — | EP | disclosed |
| EP-0798288-A1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-10-01 | — | — | EP | disclosed |