Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | CTSD | P07339 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366798 | 0.98 | GPR35 (0.56) | GPR35TSHRCTSDALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL8302538 | 0.96 | GPR35 (0.55) | GPR35TSHRCTSDALDH1A1TDP1 | |
| Aziridine SCHEMBL3049817 | 0.90 | GPR35 (0.49) | GPR35TSHRCTSDALDH1A1TDP1 | |
| SCHEMBL782562 | 0.89 | GPR35 (0.47) | GPR35TSHRCTSDALDH1A1TDP1 | |
| SCHEMBL19127226 | 0.89 | GPR35 (0.47) | GPR35TSHRCTSDALDH1A1TDP1 | |
| SCHEMBL5792626 | 0.87 | TSHR (0.48) | GPR35TSHRCTSDALDH1A1TDP1 | |
| SCHEMBL30893562 | 0.83 | TSHR (0.68) | GPR35TSHRCTSDALDH1A1TDP1 | |
| SCHEMBL3671 | 0.83 | TSHR (0.68) | GPR35TSHRCTSDALDH1A1TDP1 | |
| SCHEMBL7417028 | 0.83 | GPR35 (0.60) | GPR35TSHRCTSDALDH1A1TDP1 | |
| SCHEMBL7263414 | 0.83 | GPR35 (0.60) | GPR35TSHRCTSDALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117500483-A | Microspheres with flow-through voids as embolization and drug delivery agents | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 2024-02-02 | — | — | CN | claimed |
| CN-117500483-A | Microspheres with flow-through voids as embolization and drug delivery agents | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 2024-02-02 | — | — | CN | disclosed |
| EP-2816036-B1 | PRODRUG USING NITROIMIDAZOLE | UNIV TSUKUBA (JP) | 2019-04-17 | — | — | EP | disclosed |
| US-9655975-B2 | Prodrug using nitroimidazole | UNIVERSITY OF TSUKUBA (JP) | 2017-05-23 | — | — | US | disclosed |
| EP-2366691-B1 | THE NITROPYRIDINYL ETHYLENEIMINE COMPOUND, THE PHARMACEUTICAL COMPOSITION CONTAINING IT, THE PREPARATION METHOD AND USE THEREOF | BEIJING YILING BIOENGINEERING CO LTD (CN) | 2015-04-15 | — | — | EP | disclosed |
| US-8940770-B2 | Nitropyridinyl ethyleneimine compound, the pharmaceutical composition containing it, the preparation method and use thereof | BEIJING YILING BIOENGINEERING CO., LTD. (CN) | 2015-01-27 | — | — | US | disclosed |
| US-20140378673-A1 | PRODRUG USING NITROIMIDAZOLE | UNIVERSITY OF TSUKUBA (JP) | 2014-12-25 | — | — | US | disclosed |
| EP-2816036-A1 | PRODRUG USING NITROIMIDAZOLE | University of Tsukuba (JP) | 2014-12-24 | — | — | EP | disclosed |
| US-20140073796-A1 | NITROPYRIDINYL ETHYLENEIMINE COMPOUND, THE PHARMACEUTICAL COMPOSITION CONTAINING IT, THE PREPARATION METHOD AND USE THEREOF | BEIJING YILING BIOENGINEERING CO., LTD (CN) | 2014-03-13 | — | — | US | disclosed |
| US-8609851-B2 | Nitropyridinyl ethyleneimine compound, the pharmaceutical composition containing it, the preparation method and use thereof | BEIJING YILING BIOENGINEERING CO., LTD. (CN) | 2013-12-17 | — | — | US | disclosed |
| US-20120071515-A1 | NITROPYRIDINYL ETHYLENEIMINE COMPOUND, THE PHARMACEUTICAL COMPOSITION CONTAINING IT, THE PREPARATION METHOD AND USE THEREOF | BEIJING YILING BIOENGINEERING CO., LTD (CN) | 2012-03-22 | — | — | US | disclosed |
| EP-2366691-A1 | THE NITROPYRIDINYL ETHYLENEIMINE COMPOUND, THE PHARMACEUTICAL COMPOSITION CONTAINING IT, THE PREPARATION METHOD AND USE THEREOF | Beijing Yiling Bioengineering Co., Ltd. (CN) | 2011-09-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378673-A1 | PRODRUG USING NITROIMIDAZOLE | HIF1AN, HIF1A, PAICS | GPR35 2819/4885TSHR 4568/4885CTSD 1665/4885 |
| US-20120071515-A1 | NITROPYRIDINYL ETHYLENEIMINE COMPOUND, THE PHARMACEUTICAL COMPOSITION CONTAINING IT, THE PREPARATION METHOD AND USE THEREOF | ENPP1, DPYD, NME2 | GPR35 2108/4885TSHR 4235/4885CTSD 3016/4885 |
| US-20140073796-A1 | NITROPYRIDINYL ETHYLENEIMINE COMPOUND, THE PHARMACEUTICAL COMPOSITION CONTAINING IT, THE PREPARATION METHOD AND USE THEREOF | ENPP1, DPYD, NME2 | GPR35 2108/4885TSHR 4235/4885CTSD 3016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.