Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 10/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816740 | 0.78 | — | — | |
| SCHEMBL7813559 | 0.74 | TLR8 (0.41) | TLR8MAPTTP53SMN1; SMN2 | |
| SCHEMBL31066873 | 0.66 | TLR8 (0.68) | TLR8MAPTTP53GAASMN1; SMN2 | |
| SCHEMBL31066866 | 0.66 | TLR8 (0.68) | TLR8MAPTTP53GAASMN1; SMN2 | |
| SCHEMBL16512952 | 0.66 | TLR8 (0.74) | TLR8POLB | |
| SCHEMBL9847099 | 0.65 | TLR8 (0.72) | TLR8MAPTTP53SMN1; SMN2 | |
| SCHEMBL16486950 | 0.64 | TLR8 (1.00) | TLR8TP53POLB | |
| SCHEMBL8007799 | 0.64 | — | — | |
| SCHEMBL8142237 | 0.63 | PDE4B (0.42) | — | |
| SCHEMBL17819059 | 0.63 | TLR8 (0.69) | TLR8TP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091941-A1 | NOVEL BENZIMIDAZOLES AS CORTICOTROPIN RELEASE FACTOR ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2001-04-18 | — | — | EP | disclosed |
| US-6124463-A | TREATMENT OF AFFECTIVE DISORDER, ANXIETY OR DEPRESSION | DUPONT PHARMACEUTICALS (US) | 2000-09-26 | — | — | US | disclosed |
| WO-2000001675-A1 | NOVEL BENZIMIDAZOLES AS CORTICOTROPIN RELEASE FACTOR ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-01-13 | — | — | WO | disclosed |