Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | RAC1 | P63000 | 4/20 | 0.54 |
| ▸ | TOP2A | P11388 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | TDO2 | P48775 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3318529 | 0.87 | KDM4E (0.64) | KDM4EMAPTNPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL3316173 | 0.86 | KDM4E (0.62) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL7822956 | 0.83 | KDM4E (0.83) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL9679340 | 0.76 | NPC1 (0.58) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL3321436 | 0.73 | RAC1 (0.84) | KDM4EMAPTNPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL3318470 | 0.72 | RAC1 (0.85) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL3321880 | 0.72 | KDM4E (0.80) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL15436211 | 0.71 | KIT (0.58) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL29365587 | 0.71 | ALOX5 (0.72) | KDM4EMAPTMEN1KMT2ATOP2A | |
| SCHEMBL3324961 | 0.71 | KDM4E (1.00) | KDM4EMAPTNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888346-B1 | CORALYNE ANALOGS AS TOPOISOMERASE INHIBITORS | UNIV RUTGERS (US) | 2001-06-06 | — | — | EP | disclosed |
| EP-0888346-A1 | CORALYNE ANALOGS AS TOPOISOMERASE INHIBITORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997029106-A1 | CORALYNE ANALOGS AS TOPOISOMERASE INHIBITORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1997-08-14 | — | — | WO | disclosed |