Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 17/20 | 0.67 |
| ▸ | HTR1A | P08908 | 15/20 | 0.67 |
| ▸ | HTR2A | P28223 | 14/20 | 0.67 |
| ▸ | HTR7 | P34969 | 14/20 | 0.67 |
| ▸ | HTR6 | P50406 | 14/20 | 0.67 |
| ▸ | DRD4 | P21917 | 3/20 | 0.59 |
| ▸ | DRD5 | P21918 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815142 | 0.87 | DRD2 (0.71) | DRD2HTR1AHTR2AHTR7HTR6 | |
| Du 125530 SCHEMBL1082516 | 0.85 | HTR1A (0.68) | DRD2HTR1AHTR2AHTR7HTR6 | |
| Du 125530 SCHEMBL29403202 | 0.85 | HTR1A (0.68) | DRD2HTR1AHTR2AHTR7HTR6 | |
| Du 125530 SCHEMBL6063602 | 0.84 | HTR1A (0.67) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL7820656 | 0.84 | HTR1A (0.67) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL7815669 | 0.83 | HTR1A (0.68) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL7833008 | 0.81 | HTR1A (0.68) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL7814640 | 0.81 | HTR1A (0.65) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL7818821 | 0.80 | HTR1A (0.64) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL7817326 | 0.79 | HTR1A (0.65) | DRD2HTR1AHTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633260-B1 | 2,3-Dihydro-1,4-benzodioxan-5-yl-piperazine derivatives having 5-HT1A-antagonistic activity | DUPHAR INT RES (NL) | 2001-11-07 | — | — | EP | disclosed |
| US-5462942-A | 2,3-dihydro-1,4-benzodioxin-5-yl-piperazine derivatives having 5-HT 1A-antagonistic activity | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| EP-0633260-A1 | 2,3-Dihydro-1,4-benzodioxin-5-yl-piperazine derivatives having 5-HT1A-antagonistic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1995-01-11 | — | — | EP | disclosed |