Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6215297 | 0.88 | HPGD (0.49) | L3MBTL1HPGDKMT2AMEN1ATM | |
| SCHEMBL6283595 | 0.86 | L3MBTL1 (0.50) | L3MBTL1HPGDKMT2AMEN1ATM | |
| SCHEMBL7830310 | 0.85 | MEN1 (0.48) | L3MBTL1HPGDKMT2AMEN1ATM | |
| SCHEMBL7832968 | 0.85 | HPGD (0.47) | L3MBTL1HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7949237 | 0.84 | HPGD (0.46) | L3MBTL1HPGDKMT2AMEN1ATM | |
| SCHEMBL7960027 | 0.84 | MEN1 (0.50) | L3MBTL1HPGDKMT2AMEN1ATM | |
| SCHEMBL7959507 | 0.84 | HPGD (0.46) | L3MBTL1HPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL22067844 | 0.84 | L3MBTL1 (0.47) | L3MBTL1KMT2AMEN1MAPT | |
| SCHEMBL29455644 | 0.84 | C5AR1 (0.48) | L3MBTL1HPGDKMT2AMEN1ATM | |
| Hydrochloric Acid SCHEMBL7957421 | 0.83 | MEN1 (0.49) | L3MBTL1HPGDKMT2AMEN1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |