Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7957421 | 0.99 | MEN1 (0.49) | MEN1KMT2AHPGDCYP3A4SMN1; SMN2 | |
| SCHEMBL7959507 | 0.89 | HPGD (0.46) | MEN1KMT2AHPGDCYP3A4SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7961055 | 0.88 | HPGD (0.45) | MEN1KMT2AHPGDCYP3A4SMN1; SMN2 | |
| SCHEMBL7830310 | 0.88 | MEN1 (0.48) | MEN1KMT2AHPGDCYP3A4SMN1; SMN2 | |
| SCHEMBL7822161 | 0.84 | L3MBTL1 (0.56) | MEN1KMT2AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL6283595 | 0.78 | L3MBTL1 (0.50) | MEN1KMT2AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL7832968 | 0.77 | HPGD (0.47) | MEN1KMT2AHPGDSMN1; SMN2BRD4 | |
| SCHEMBL6215297 | 0.76 | HPGD (0.49) | MEN1KMT2AHPGDBRD4ATM | |
| SCHEMBL7949237 | 0.76 | HPGD (0.46) | MEN1KMT2AHPGDBRD4ATM | |
| SCHEMBL7959350 | 0.75 | MEN1 (0.45) | MEN1KMT2AALDH1A1TDP1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232318-B1 | COMPOUNDS SUCH AS 1-BENZYL-3-(3-(4-(4-FLUOROPHENYL)PIPERIDIN -1-YL)PROPYL)-5-METHYL-1H-PYRIMIDINE-2,4-DIONE; PROVIDES RELIEF TO MALES SUFFERING FROM BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., LTD. | 2001-05-15 | — | — | US | disclosed |
| WO-2000029386-A1 | PYRIMIDINEDIONE DERIVATIVES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-25 | — | — | WO | disclosed |