Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 6/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821575 | 0.90 | TOP2A (0.35) | TOP2ABRD4DYRK1APDE2AAAK1 | |
| SCHEMBL7818284 | 0.82 | NQO2 (0.38) | TOP2ABCHECNR2 | |
| SCHEMBL7821158 | 0.80 | TOP2A (0.35) | TOP2ABRD4BCHECNR2 | |
| SCHEMBL7816796 | 0.80 | TOP2A (0.44) | TOP2ABRD4MALT1DDB1CRBN | |
| SCHEMBL7804755 | 0.80 | TOP2A (0.44) | TOP2ABRD4MALT1DDB1CRBN | |
| SCHEMBL7819175 | 0.78 | NQO2 (0.39) | BCHECNR2 | |
| SCHEMBL7819756 | 0.75 | TOP2A (0.45) | TOP2ABRD4MALT1DDB1CRBN | |
| SCHEMBL7814301 | 0.75 | ECE1 (0.46) | TOP2ABRD4MALT1DDB1CRBN | |
| SCHEMBL8848031 | 0.74 | TOP2A (0.54) | TOP2ABRD4MALT1DDB1CRBN | |
| SCHEMBL8848197 | 0.74 | TOP2A (0.54) | TOP2ABRD4MALT1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |