Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 8/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 3/20 | 0.33 |
| ▸ | NQO1 | P15559 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ECE1 | P42892 | 1/20 | 0.31 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818284 | 0.95 | NQO2 (0.38) | TOP2ACNR2BCHEACHENQO2 | |
| SCHEMBL7819175 | 0.88 | NQO2 (0.39) | CNR2BCHEACHENQO2NQO1 | |
| SCHEMBL7817848 | 0.85 | TOP2A (0.40) | TOP2ACNR2BCHEACHENQO1 | |
| SCHEMBL7818947 | 0.81 | TOP2A (0.44) | TOP2ANQO2NQO1ECE1MUS81 | |
| SCHEMBL7822606 | 0.80 | TOP2A (0.36) | TOP2ACNR2BCHEBRD4 | |
| SCHEMBL7804809 | 0.78 | ECE1 (0.47) | TOP2AECE1MUS81SMN1; SMN2 | |
| SCHEMBL7804602 | 0.78 | ECE1 (0.47) | TOP2AECE1MUS81 | |
| SCHEMBL7817109 | 0.76 | TOP2A (0.44) | TOP2A | |
| SCHEMBL7809103 | 0.75 | TOP2A (0.46) | TOP2ANQO2NQO1SMN1; SMN2 | |
| SCHEMBL7809335 | 0.74 | TOP2A (0.44) | TOP2ANQO2NQO1ECE1MUS81 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | disclosed |
| EP-0775143-A1 | NEW 3-SUBSTITUTED 3H-2,3-BENZODIAZEPINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-28 | — | — | EP | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |
| EP-0750619-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1997-01-02 | — | — | EP | disclosed |
| WO-1996004283-A1 | NEW 3-SUBSTITUTED 3H-2,3-BENZODIAZEPINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-02-15 | — | — | WO | disclosed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |