Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | PGK2 | P07205 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8012694 | 0.87 | KDM4E (0.39) | KDM4EALDH1A1HPGDHTTRECQL | |
| SCHEMBL19358702 | 0.83 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGDHTTRECQL | |
| SCHEMBL4704967 | 0.80 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDHTTRECQL | |
| SCHEMBL2423817 | 0.79 | KDM4E (0.47) | KDM4EALDH1A1HPGDHTTRECQL | |
| SCHEMBL7846199 | 0.79 | KDM4E (0.42) | KDM4EALDH1A1HPGDHTTRECQL | |
| Hydrochloric Acid SCHEMBL5741762 | 0.79 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGDHTTRECQL | |
| SCHEMBL8015267 | 0.79 | KMT2A (0.44) | KDM4EALDH1A1HPGDHTTRECQL | |
| SCHEMBL5742547 | 0.75 | KDM4E (0.39) | KDM4EALDH1A1HPGDHTTRECQL | |
| SCHEMBL20477417 | 0.75 | SMN1; SMN2 (0.56) | KDM4EALDH1A1HPGDCYP1A2MEN1 | |
| SCHEMBL8015619 | 0.75 | KDM4E (0.41) | KDM4EALDH1A1HPGDHTTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880522-B1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES AMPA AND NMDA RECEPTORS ANTAGONISTS, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2001-09-19 | — | — | EP | disclosed |
| EP-0880522-A1 | 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997025328-A1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1997-07-17 | — | — | WO | disclosed |