SCHEMBL7822855

SCHEMBL7822855

C/C(=C\c1ccc(Cl)cc1Cl)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.56
GABRG2 P18507 1/20 0.56
GABRB3 P28472 1/20 0.56
TDP1 Q9NUW8 1/20 0.50
MAPT P10636 4/20 0.45
ALDH1A1 P00352 4/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
RAB9A P51151 2/20 0.45
NPC1 O15118 1/20 0.45
POLB P06746 1/20 0.45
KDM4E B2RXH2 1/20 0.45
GAA P10253 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
AKR1C3 P42330 1/20 0.44
TSHR P16473 1/20 0.44
CASP1 P29466 1/20 0.44
FSCN1 Q16658 1/20 0.42
TP53 P04637 2/20 0.42
CYP1A2 P05177 1/20 0.41
CYP2C19 P33261 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7822858 1.00 GABRA1 (0.56) GABRA1GABRG2GABRB3TDP1MAPT
SCHEMBL2394989 0.84 AKR1C3 (0.43) GABRA1GABRG2GABRB3TDP1ALDH1A1
SCHEMBL2394991 0.84 AKR1C3 (0.43) GABRA1GABRG2GABRB3TDP1ALDH1A1
SCHEMBL1745376 0.84 TTR (0.53) GABRA1GABRG2GABRB3POLBKDM4E
SCHEMBL27322404 0.84 AKR1C3 (0.43) GABRA1GABRG2GABRB3TDP1MAPT
SCHEMBL1745377 0.84 TTR (0.53) GABRA1GABRG2GABRB3POLBKDM4E
SCHEMBL1407820 0.83 GABRA1 (0.53) GABRA1GABRG2GABRB3TDP1MAPT
SCHEMBL1407819 0.83 GABRA1 (0.53) GABRA1GABRG2GABRB3TDP1MAPT
SCHEMBL7880140 0.83 ABL1 (0.42) GABRA1GABRG2GABRB3TDP1MAPT
SCHEMBL7880143 0.83 ABL1 (0.42) GABRA1GABRG2GABRB3TDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11896593-B2 Sulfamate derivative compounds for use in treating or alleviating a psychiatric disorder BIO-PHARM SOLUTIONS CO., LTD. (KR) 2024-02-13 US disclosed
EP-4211125-A1 SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING A PSYCHIATRIC DISORDER Bio-Pharm Solutions Co., Ltd. (KR) 2023-07-19 EP disclosed
US-20220218702-A1 SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING A PSYCHIATRIC DISORDER BIO-PHARM SOLUTIONS CO., LTD. (KR) 2022-07-14 US disclosed
WO-2022054987-A1 SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING A PSYCHIATRIC DISORDER BIO-PHARM SOLUTIONS CO., LTD. (KR) 2022-03-17 WO disclosed
EP-3443959-A1 SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING PAIN Bio-Pharm Solutions Co., Ltd. (KR) 2019-02-20 EP disclosed
EP-3079685-B1 SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING PAIN BIO PHARM SOLUTIONS CO LTD (KR) 2018-11-28 EP disclosed
EP-3079686-B1 SULFAMATE DERIVATIVE COMPOUND FOR USE IN PREVENTING OR TREATING EPILEPSY BIO PHARM SOLUTIONS CO LTD (KR) 2018-10-24 EP disclosed
US-9937145-B2 Sulfamate derivative compound for use in preventing or treating epilepsy BIO-PHARM SOLUTIONS CO., LTD. (KR) 2018-04-10 US disclosed
US-9834535-B2 Sulfamate derivative compounds for use in treating or alleviating pain BIO-PHARM SOLUTIONS CO., LTD. (KR) 2017-12-05 US disclosed
EP-2861571-B1 PHENYLALKYL SULFAMATE COMPOUND AND MUSCLE RELAXANT COMPOSITION COMPRISING THE SAME BIO-PHARM SOLUTIONS CO LTD (KR) 2017-05-03 EP disclosed
WO-2013187727-A1 PHENYLALKYL SULFAMATE COMPOUND AND MUSCLE RELAXANT COMPOSITION COMPRISING THE SAME BIO-PHARM SOLUTIONS CO., LTD. (KR) 2013-12-19 WO disclosed
EP-1091958-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2001-04-18 EP disclosed
WO-2000001692-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2000-01-13 WO disclosed
EP-0765351-B1 AMIDATION OF ESTER FUNCTIONALIZED HYDROCARBON POLYMERS EXXON CHEMICAL PATENTS INC (US) 1999-01-13 EP disclosed
US-5627259-A REACTION OF OLEFIN POLYMERS WITH CARBON MONOXIDE AND ALCOHOL THEN REACTION OF ESTER WITH POLYAMINE COMPOUND RELEASING ALCOHOL COMPOUND EXXON CHEMICAL PATENTS INC. (US) 1997-05-06 US disclosed
EP-0765351-A1 AMIDATION OF ESTER FUNCTIONALIZED HYDROCARBON POLYMERS EXXON CHEMICAL PATENTS INC. (US) 1997-04-02 EP disclosed
WO-1995035330-A1 AMIDATION OF ESTER FUNCTIONALIZED HYDROCARBON POLYMERS EXXON CHEMICAL PATENTS INC. (US) 1995-12-28 WO disclosed
EP-0607344-A1 3,4-DIHYDRO-4-OXO-3-(PROP-2-ENYL)-1-PHTALAZINEACETIC ACIDS AND DERIVATIVES, PREPARATIONS THEREOF AND DRUGS CONTAINING SAME LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) 1994-07-27 EP disclosed
WO-1993007109-A1 3,4-DIHYDRO-4-OXO-3-(PROP-2-ENYL)-1-PHTALAZINEACETIC ACIDS AND DERIVATIVES, PREPARATIONS THEREOF AND DRUGS CONTAINING SAME LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) 1993-04-15 WO disclosed
EP-0099165-A1 Triazole and imidazole compounds, process for their preparation and their use as fungicides and plant growth regulators, and intermediates for their synthesis IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-01-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220218702-A1 SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING A PSYCHIATRIC DISORDER SLC6A4, SLC6A3, SLC6A2 GABRA1 120/4885GABRG2 147/4885GABRB3 113/4885
US-11896593-B2 Sulfamate derivative compounds for use in treating or alleviating a psychiatric disorder SLC6A4, SLC6A3, SLC6A2 GABRA1 120/4885GABRG2 147/4885GABRB3 113/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.