SCHEMBL7822972

SCHEMBL7822972

O=C(O)/C=C/c1ccccc1Sc1ccc2ccccc2c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER3 P43115 4/20 0.57
ITGB2 P05107 1/20 0.56
ICAM1 P05362 1/20 0.56
ITGAL P20701 1/20 0.56
PTGDR Q13258 3/20 0.53
TBXA2R P21731 2/20 0.53
PTGER2 P43116 2/20 0.53
PTGER4 P35408 1/20 0.53
PTGFR P43088 1/20 0.53
HDAC1 Q13547 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
CCNC P24863 1/20 0.47
CDK8 P49336 1/20 0.47
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
NFKB1 P19838 1/20 0.46
CA4 P22748 1/20 0.46
PTGES O14684 1/20 0.44
HTT P42858 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7931764 1.00 PTGER3 (0.57) PTGER3ITGB2ICAM1ITGALPTGDR
SCHEMBL18812999 0.84 ITGB2 (0.60) PTGER3ITGB2ICAM1ITGALPTGDR
SCHEMBL7650686 0.82 ITGB2 (0.69) PTGER3ITGB2ICAM1ITGALPTGDR
SCHEMBL6759583 0.81 PTGES (0.61) PTGER3ITGB2ICAM1ITGALPTGDR
SCHEMBL6759585 0.81 PTGES (0.61) PTGER3ITGB2ICAM1ITGALPTGDR
SCHEMBL6766087 0.81 HDAC1 (0.72) PTGER3ITGB2ICAM1ITGALPTGDR
SCHEMBL6766091 0.81 HDAC1 (0.72) PTGER3ITGB2ICAM1ITGALPTGDR
SCHEMBL31241186 0.78 PTGER3 (0.45) PTGER3HDAC1HDAC8HDAC6SMN1; SMN2
SCHEMBL3674814 0.78 PTGER3 (0.45) PTGER3HDAC1HDAC8HDAC6SMN1; SMN2
SCHEMBL8746635 0.75 CA1 (0.59) PTGER3PTGDRTBXA2RPTGER2PTGER4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6242493-B1 PROSTAGLANDIN INHIBITORS; ANALGESICS, ANTIPYRETICS, ANTIINFLAMMATORY AGENTS MERCK FROSST CANADA & CO. (CA) 2001-06-05 US disclosed
EP-1071648-A2 CARBOXYLIC ACIDS AND ACYLSULFONAMIDES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT Merck Frosst Canada & Co. (CA) 2001-01-31 EP disclosed
WO-1999047497-A2 CARBOXYLIC ACIDS AND ACYLSULFONAMIDES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT MERCK FROSST CANADA & CO. (CA) 1999-09-23 WO disclosed