Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.53 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.53 |
| ▸ | ITGAL | P20701 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6759585 | 1.00 | PTGES (0.61) | PTGESHDAC1HDAC8HDAC6ITGB2 | |
| SCHEMBL18812999 | 0.89 | ITGB2 (0.60) | PTGESHDAC1HDAC8HDAC6ITGB2 | |
| SCHEMBL6766087 | 0.85 | HDAC1 (0.72) | PTGESHDAC1HDAC8HDAC6ITGB2 | |
| SCHEMBL6766091 | 0.85 | HDAC1 (0.72) | PTGESHDAC1HDAC8HDAC6ITGB2 | |
| SCHEMBL7650686 | 0.84 | ITGB2 (0.69) | HDAC1HDAC8HDAC6ITGB2ICAM1 | |
| SCHEMBL6761158 | 0.82 | ALDH1A1 (0.52) | PTGESHDAC1HDAC8HDAC6CA1 | |
| SCHEMBL6761159 | 0.82 | ALDH1A1 (0.52) | PTGESHDAC1HDAC8HDAC6CA1 | |
| SCHEMBL6759562 | 0.81 | ITGB2 (0.60) | PTGESITGB2ICAM1ITGALNFKB1 | |
| SCHEMBL6759567 | 0.81 | ITGB2 (0.60) | PTGESITGB2ICAM1ITGALNFKB1 | |
| SCHEMBL7822972 | 0.81 | PTGER3 (0.57) | PTGESHDAC1HDAC8HDAC6ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040192680-A1 | Novel amides that activate soluble guanylate cyclase | ABBOTT LABORATORIES | 2004-09-30 | — | — | US | disclosed |
| US-20040121994-A1 | Novel amides that activate soluble guanylate cyclase | ABBOTT LABORATORIES | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040121994-A1 | Novel amides that activate soluble guanylate cyclase | GUCY1A1, GUCY1B1, GUCY1A2 | PTGES 739/4885HDAC1 1108/4885HDAC8 2330/4885 |
| US-20040192680-A1 | Novel amides that activate soluble guanylate cyclase | GUCY1A1, GUCY1B1, GUCY1A2 | PTGES 739/4885HDAC1 1108/4885HDAC8 2330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.