Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 18/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.43 |
| ▸ | ITGAV | P06756 | 13/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 7/20 | 0.42 |
| ▸ | ITGB6 | P18564 | 5/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.42 |
| ▸ | ITGB8 | P26012 | 3/20 | 0.42 |
| ▸ | ITGA8 | P53708 | 3/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.39 |
| ▸ | MDM4 | O15151 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | F7 | P08709 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835572 | 0.86 | ITGB3 (0.45) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL7835493 | 0.86 | ITGB3 (0.53) | ITGB3ITGAVITGB1ITGA5ITGB6 | |
| SCHEMBL6777052 | 0.86 | ITGB3 (0.59) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL242674 | 0.83 | ITGB3 (0.55) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL6778464 | 0.82 | ITGB3 (0.46) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL6778074 | 0.82 | GPR139 (0.47) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL6776850 | 0.82 | ITGB3 (0.49) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL6776866 | 0.82 | ITGB3 (0.53) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL6779116 | 0.82 | ITGB3 (0.51) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL6779560 | 0.82 | ITGB3 (0.50) | ITGB3ITGA2BITGAVITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |