Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 18/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 18/20 | 0.51 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821774 | 0.88 | HIF1A (0.48) | HIF1AEPAS1EP300NR1H3 | |
| SCHEMBL7819712 | 0.87 | HIF1A (0.65) | HIF1AEPAS1EP300 | |
| SCHEMBL7820331 | 0.85 | HIF1A (0.48) | HIF1AEPAS1EP300 | |
| SCHEMBL7826302 | 0.85 | HIF1A (0.60) | HIF1AEPAS1EP300 | |
| SCHEMBL7820055 | 0.83 | HIF1A (0.60) | HIF1AEPAS1EP300 | |
| SCHEMBL9201152 | 0.79 | HIF1A (0.53) | HIF1AEPAS1EP300 | |
| SCHEMBL7825817 | 0.77 | HIF1A (0.49) | HIF1AEPAS1EP300 | |
| SCHEMBL7766906 | 0.76 | ALDH1A1 (0.42) | HIF1AEPAS1 | |
| SCHEMBL7822894 | 0.76 | HIF1A (0.57) | HIF1AEPAS1EP300 | |
| SCHEMBL8813555 | 0.76 | HIF1A (0.49) | HIF1AEPAS1EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828733-B1 | BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NOVARTIS AG (CH) | 2001-09-05 | — | — | EP | disclosed |
| US-5905156-A | POTASSIUM CHANNEL ACTIVATORS AND BRONCHODILATORS | NOVARTIS AG (CH) | 1999-05-18 | — | — | US | disclosed |