Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 3/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.48 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5353568 | 0.89 | HSD11B1 (0.56) | CCR3HSD11B1EPHX1EPHX2CNR2 | |
| SCHEMBL7814141 | 0.81 | CCR3 (0.77) | CCR3HSD11B1GRM5GRM7GRM3 | |
| SCHEMBL7823461 | 0.77 | CCR3 (0.59) | CCR3HSD11B1 | |
| SCHEMBL7814197 | 0.75 | CCR3 (0.77) | CCR3 | |
| SCHEMBL13873302 | 0.75 | EPHX2 (0.55) | EPHX1EPHX2CNR2 | |
| SCHEMBL5351408 | 0.73 | CCR3 (1.00) | CCR3 | |
| SCHEMBL6331510 | 0.73 | CCR3 (0.81) | CCR3EPHX1EPHX2 | |
| SCHEMBL6337374 | 0.72 | CCR3 (0.77) | CCR3EPHX1EPHX2TMEM97 | |
| SCHEMBL6338952 | 0.72 | EPHX2 (0.55) | CCR3EPHX1EPHX2 | |
| SCHEMBL6407882 | 0.72 | CCR3 (0.65) | CCR3EPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140834-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000035877-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-06-22 | — | — | WO | claimed |
| EP-1140834-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035877-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |