Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5816298 | 0.79 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL30491568 | 0.79 | CYP2C19 (0.49) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL29788860 | 0.79 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL29788836 | 0.79 | CYP19A1 (0.45) | TYRMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL305310 | 0.75 | CYP19A1 (0.58) | TYRCYP2A13 | |
| SCHEMBL29788845 | 0.75 | KMT2A (0.54) | MEN1KMT2AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL2532477 | 0.73 | CYP19A1 (0.55) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL9978689 | 0.72 | CYP19A1 (0.53) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL8112945 | 0.71 | RAB9A (0.40) | MEN1KMT2AALDH1A1KDM4EHMOX1 | |
| SCHEMBL708243 | 0.70 | KDM4E (0.51) | TYRMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880522-B1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES AMPA AND NMDA RECEPTORS ANTAGONISTS, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2001-09-19 | — | — | EP | disclosed |
| EP-0880522-A1 | 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997025328-A1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1997-07-17 | — | — | WO | disclosed |