Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7823614 | 1.00 | VNN1 (0.46) | VNN1CYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3243595 | 0.83 | VNN1 (0.43) | VNN1CYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL9302450 | 0.82 | VNN1 (0.42) | VNN1CYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL9302445 | 0.82 | VNN1 (0.42) | VNN1CYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL9661857 | 0.81 | KCNA5 (0.44) | VNN1CYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL9661853 | 0.81 | KCNA5 (0.44) | VNN1CYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7826774 | 0.79 | KMT2A (0.37) | CYP2C9CYP1A2CYP3A4CYP2C19HIF1A | |
| SCHEMBL7826776 | 0.79 | KMT2A (0.37) | CYP2C9CYP1A2CYP3A4CYP2C19HIF1A | |
| SCHEMBL7675394 | 0.77 | CYP1A2 (0.69) | CYP2C9CYP1A2CYP3A4CYP2C19HIF1A | |
| SCHEMBL8309619 | 0.74 | VNN1 (0.38) | VNN1CYP2C9CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0500864-B1 | ANTIMUSCARINIC BRONCHODILATORS | PFIZER LTD (GB) | 2001-09-19 | — | — | EP | disclosed |
| US-5292749-A | Quinuclidine derivatives; bronchodilator agents, treatment of respiratory system disorders | PFIZER INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0500864-A1 | ANTIMUSCARINIC BRONCHODILATORS | Pfizer Limited (GB) | 1992-09-02 | — | — | EP | disclosed |
| WO-1992004346-A1 | ANTIMUSCARINIC BRONCHODILATORS | PFIZER LIMITED (GB) | 1992-03-19 | — | — | WO | disclosed |