Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828521 | 0.89 | TP53 (0.39) | FFAR1IDO1TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL7828984 | 0.87 | EPHX1 (0.46) | LDHAEPHX1IDO1TP53SMN1; SMN2 | |
| SCHEMBL7824133 | 0.85 | LDHA (0.39) | FFAR1LDHAEPHX1IDO1TP53 | |
| SCHEMBL8823362 | 0.82 | LDHA (0.46) | FFAR1LDHAEPHX1IDO1SMN1; SMN2 | |
| SCHEMBL7827231 | 0.80 | LDHA (0.44) | FFAR1LDHAEPHX1IDO1ALDH1A1 | |
| SCHEMBL7825227 | 0.80 | LDHA (0.39) | FFAR1LDHAEPHX1IDO1TP53 | |
| SCHEMBL812289 | 0.79 | MAPT (0.45) | FFAR1LDHAEPHX1IDO1ALDH1A1 | |
| SCHEMBL7816648 | 0.77 | KDM1A (0.40) | FFAR1LDHAEPHX1TP53ALDH1A1 | |
| SCHEMBL7831583 | 0.75 | HTT (0.45) | EPHX1IDO1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL769100 | 0.74 | SMN1; SMN2 (0.43) | FFAR1LDHAEPHX1IDO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745081-B1 | INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMA INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-0656001-B1 | NOVEL 2-SUBSTITUTED INDANE-2-MERCAPTOACETYLAMIDE TRICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMA INC (US) | 1999-09-15 | — | — | EP | disclosed |
| EP-0534363-B1 | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMA INC (US) | 1997-07-09 | — | — | EP | disclosed |
| US-5604221-A | Indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase | MERRELL PHARMACEUTICALS INC. (US) | 1997-02-18 | — | — | US | disclosed |
| EP-0745081-A1 | NOVEL INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-04 | — | — | EP | disclosed |
| US-5529996-A | USEFUL FOR CONGESTIVE HEART FAILURE, DIURETIC EFFECT, IRRITABLE BOWL MOVEMENT, ENDORPHIN OR ENKEPHALIN MEDIATED ANALGESIC EFFECTS AND ALSO HYPOTENSIVE AGENT | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-06-25 | — | — | US | disclosed |
| US-5491142-A | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5491141-A | ENZYME INHIBITORS, HYPERTENSIVE AGENTS; TREATING DIURETIC, CONGESTIVE HEART FAILURE, ALDOSTERONISM, RENAL DISEASES, GLAUCOMA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5486513-A | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors or enkephalinase and ace | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-01-23 | — | — | US | disclosed |
| WO-1995021840-A1 | NOVEL INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-17 | — | — | WO | disclosed |
| US-5428158-A | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0656001-A1 | NOVEL 2-SUBSTITUTED INDANE-2-MERCAPTOACETYLAMIDE TRICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-07 | — | — | EP | disclosed |
| US-5420271-A | Analgesics, cardiovascular disorders, diuretics or hypoaldosteronemic agents | MERRELL DOW PHARMACEUTICALS, INC. (US) | 1995-05-30 | — | — | US | disclosed |
| WO-1994004531-A1 | NOVEL 2-SUBSTITUTED INDANE-2-MERCAPTOACETYLAMIDE TRICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-03 | — | — | WO | disclosed |
| EP-0534363-A2 | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1993-03-31 | — | — | EP | disclosed |