Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.42 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7827231 | 0.94 | LDHA (0.44) | LDHAIDO1EPHX1FFAR1SMN1; SMN2 | |
| SCHEMBL812289 | 0.93 | MAPT (0.45) | LDHAIDO1EPHX1FFAR1SMN1; SMN2 | |
| SCHEMBL769100 | 0.88 | SMN1; SMN2 (0.43) | LDHAIDO1EPHX1FFAR1SMN1; SMN2 | |
| SCHEMBL7828984 | 0.84 | EPHX1 (0.46) | LDHAIDO1EPHX1SMN1; SMN2L3MBTL1 | |
| SCHEMBL8823363 | 0.82 | KMT2A (0.49) | IDO1L3MBTL1POLB | |
| SCHEMBL7825227 | 0.82 | LDHA (0.39) | LDHAIDO1EPHX1FFAR1SMN1; SMN2 | |
| SCHEMBL7824133 | 0.82 | LDHA (0.39) | LDHAIDO1EPHX1FFAR1SMN1; SMN2 | |
| SCHEMBL7825219 | 0.82 | FFAR1 (0.41) | LDHAIDO1EPHX1FFAR1SMN1; SMN2 | |
| SCHEMBL7829414 | 0.82 | KDM1A (0.48) | SMN1; SMN2HTT | |
| SCHEMBL7827049 | 0.81 | MAPT (0.45) | IDO1SMN1; SMN2HTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0534363-B1 | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMA INC (US) | 1997-07-09 | — | — | EP | disclosed |
| US-5529996-A | USEFUL FOR CONGESTIVE HEART FAILURE, DIURETIC EFFECT, IRRITABLE BOWL MOVEMENT, ENDORPHIN OR ENKEPHALIN MEDIATED ANALGESIC EFFECTS AND ALSO HYPOTENSIVE AGENT | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-06-25 | — | — | US | disclosed |
| US-5486513-A | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors or enkephalinase and ace | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-01-23 | — | — | US | disclosed |
| US-5428158-A | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0534363-A2 | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1993-03-31 | — | — | EP | disclosed |