Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.43 |
| ▸ | FNTA | P49354 | 15/20 | 0.39 |
| ▸ | FNTB | P49356 | 15/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.37 |
| ▸ | CPA1 | P15085 | 1/20 | 0.36 |
| ▸ | HRAS | P01112 | 1/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7841905 | 0.99 | CYP19A1 (0.43) | CYP19A1FNTAFNTBPGGT1BCPA1 | |
| SCHEMBL8149727 | 0.78 | CYP19A1 (0.52) | CYP19A1FNTAFNTBPGGT1BHRAS | |
| Hydrochloric Acid SCHEMBL3842211 | 0.78 | CYP19A1 (0.51) | CYP19A1FNTAFNTBPGGT1BHRAS | |
| SCHEMBL7826548 | 0.77 | FNTA (0.44) | CYP19A1FNTAFNTBPGGT1BCPA1 | |
| SCHEMBL8147489 | 0.77 | FNTA (0.48) | CYP19A1FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL7834168 | 0.77 | FNTA (0.44) | CYP19A1FNTAFNTBPGGT1BCPA1 | |
| Hydrochloric Acid SCHEMBL7837910 | 0.75 | FNTA (0.58) | CYP19A1FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL7656506 | 0.72 | FNTA (0.45) | CYP19A1FNTAFNTBPGGT1BHRAS | |
| SCHEMBL7836006 | 0.71 | FNTA (0.53) | CYP19A1FNTAFNTBPGGT1BHRAS | |
| SCHEMBL7466662 | 0.71 | CYP19A1 (0.44) | CYP19A1FNTAFNTBPGGT1BCPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891350-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-01-17 | — | — | EP | claimed |
| EP-0891350-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036889-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | claimed |