Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPY2R | P49146 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7829333 | 0.91 | CCR3 (0.56) | ALDH1A1MAPTCCR3 | |
| SCHEMBL7826515 | 0.86 | CCR3 (0.51) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7825838 | 0.84 | CCR3 (0.68) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7820925 | 0.83 | FAAH (0.59) | SMN1; SMN2CCR3MEN1KMT2A | |
| SCHEMBL7821529 | 0.81 | CCR3 (0.66) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7814752 | 0.81 | CCR3 (0.73) | ALDH1A1CCR3 | |
| SCHEMBL7821726 | 0.79 | CCR3 (0.69) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7829377 | 0.78 | CCR3 (0.56) | CCR3 | |
| SCHEMBL7826518 | 0.76 | CCR3 (0.58) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7822009 | 0.75 | CCR3 (0.75) | MAPTCCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140834-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035877-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |