Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 8/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7829336 | 0.90 | CCR3 (0.76) | CCR3MAPT | |
| SCHEMBL7829620 | 0.89 | CCR3 (0.75) | CCR3RAB9APOLBLMNA | |
| SCHEMBL7821529 | 0.88 | CCR3 (0.66) | CCR3RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7826518 | 0.87 | CCR3 (0.58) | CCR3RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7814917 | 0.85 | CCR3 (0.77) | CCR3 | |
| SCHEMBL7821497 | 0.84 | CCR3 (0.57) | CCR3RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7825834 | 0.84 | RAB9A (0.51) | CCR3RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7822009 | 0.83 | CCR3 (0.75) | CCR3MAPT | |
| SCHEMBL7821726 | 0.82 | CCR3 (0.69) | CCR3RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7826536 | 0.81 | CCR3 (0.75) | CCR3RAB9APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140834-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035877-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |