Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.76 |
| ▸ | CDK4 | P11802 | 5/20 | 0.72 |
| ▸ | CCND1 | P24385 | 5/20 | 0.72 |
| ▸ | FLT4 | P35916 | 5/20 | 0.72 |
| ▸ | TEK | Q02763 | 5/20 | 0.72 |
| ▸ | IGF1R | P08069 | 4/20 | 0.72 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.72 |
| ▸ | KIT | P10721 | 4/20 | 0.72 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.72 |
| ▸ | FLT1 | P17948 | 4/20 | 0.72 |
| ▸ | CDK2 | P24941 | 3/20 | 0.72 |
| ▸ | EGFR | P00533 | 3/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.72 |
| ▸ | GSK3B | P49841 | 3/20 | 0.72 |
| ▸ | ABL1 | P00519 | 2/20 | 0.72 |
| ▸ | PLK4 | O00444 | 2/20 | 0.72 |
| ▸ | AURKA | O14965 | 2/20 | 0.72 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.72 |
| ▸ | SRC | P12931 | 2/20 | 0.72 |
| ▸ | FLT3 | P36888 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethyl Acetate SCHEMBL9086300 | 0.88 | KDR (0.61) | KDRCDK4CCND1FLT4TEK | |
| SCHEMBL7814853 | 0.87 | KDR (0.58) | KDRCDK4CCND1FLT4TEK | |
| SCHEMBL1155008 | 0.86 | KDR (1.00) | KDRCDK4CCND1FLT4TEK | |
| SCHEMBL7825953 | 0.85 | SIRT2 (0.72) | KDRCDK4CCND1FLT4TEK | |
| SCHEMBL7815879 | 0.84 | CDK4 (0.73) | KDRCDK4CCND1FLT4TEK | |
| SCHEMBL9085267 | 0.84 | CDK4 (0.87) | KDRCDK4CCND1FLT4TEK | |
| Maleimide SCHEMBL1155440 | 0.84 | KDR (1.00) | KDRCDK4CCND1FLT4TEK | |
| SCHEMBL9086343 | 0.83 | PRKCB (0.67) | KDRCDK4CCND1FLT4TEK | |
| SCHEMBL9085502 | 0.83 | PRKCB (0.67) | KDRCDK4CCND1FLT4TEK | |
| Ro-316233 SCHEMBL624896 | 0.83 | PRKCB (1.00) | KDRCDK4CCND1FLT4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397060-B1 | Maleinimide derivatives and their use as medicines | GOEDECKE AG (DE) | 2001-11-21 | — | — | EP | claimed |
| US-5380746-A | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1995-01-10 | — | — | US | claimed |
| EP-0397060-A2 | Maleinimide derivatives and their use as medicines | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1990-11-14 | — | — | EP | claimed |
| EP-0397060-B1 | Maleinimide derivatives and their use as medicines | GOEDECKE AG (DE) | 2001-11-21 | — | — | EP | disclosed |
| US-5516915-A | Bis-(1H-indol-3-yl)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1996-05-14 | — | — | US | disclosed |
| US-5380746-A | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1995-01-10 | — | — | US | disclosed |
| EP-0397060-A2 | Maleinimide derivatives and their use as medicines | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1990-11-14 | — | — | EP | disclosed |