SCHEMBL78270

SCHEMBL78270

COC[C@H](CC(=O)OC)NC(=O)OCc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTRB1 P17538 2/20 0.56
SYK P43405 1/20 0.50
ATM Q13315 2/20 0.49
CASP1 P29466 4/20 0.48
ALDH1A1 P00352 2/20 0.48
TRPM8 Q7Z2W7 1/20 0.48
ALOX15 P16050 1/20 0.48
KYNU Q16719 1/20 0.47
ABCB1 P08183 1/20 0.47
CTSK P43235 2/20 0.47
LMNA P02545 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
CYP2C9 P11712 2/20 0.46
CYP2C19 P33261 2/20 0.46
CYP1A2 P05177 1/20 0.46
POLB P06746 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
TSHR P16473 1/20 0.46
CTSL P07711 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10966776 0.92 CTRB1 (0.61) CTRB1SYKATMCASP1ALDH1A1
SCHEMBL29012301 0.91 CTRB1 (0.52) CTRB1SYKATMCASP1ALDH1A1
SCHEMBL25636671 0.91 CTRB1 (0.52) CTRB1SYKATMCASP1ALDH1A1
SCHEMBL30141469 0.91 CTRB1 (0.52) CTRB1SYKATMCASP1ALDH1A1
SCHEMBL24461288 0.90 CTRB1 (0.57) CTRB1SYKATMCASP1ALDH1A1
SCHEMBL29012282 0.90 CTRB1 (0.57) CTRB1SYKATMCASP1ALDH1A1
SCHEMBL25635629 0.89 SYK (0.60) CTRB1SYKATMCASP1ALDH1A1
SCHEMBL14530318 0.88 SYK (0.60) CTRB1SYKATMCASP1ALDH1A1
SCHEMBL79250 0.88 CTRB1 (0.57) CTRB1SYKATMCASP1ALDH1A1
SCHEMBL555191 0.88 CTRB1 (0.57) CTRB1SYKATMCASP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8129538-B1 Renin inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2012-03-06 US disclosed