Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.51 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7826768 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2POLBSIGMAR1S1PR5CXCR4 | |
| SCHEMBL8329828 | 0.92 | POLB (0.59) | SMN1; SMN2POLBSIGMAR1S1PR5DRD4 | |
| SCHEMBL4034621 | 0.91 | SMN1; SMN2 (0.61) | SMN1; SMN2POLBSIGMAR1S1PR5CXCR4 | |
| SCHEMBL3609866 | 0.88 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBSIGMAR1S1PR5DRD4 | |
| SCHEMBL4847846 | 0.84 | ALDH1A1 (0.56) | SIGMAR1CXCR4KDM4EALDH1A1MEN1 | |
| SCHEMBL27341678 | 0.82 | DRD4 (0.47) | SMN1; SMN2DRD4KDM4EALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL30902435 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2DRD4KDM4EALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL30902330 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2DRD4KDM4EALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL30902328 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2DRD4KDM4EALDH1A1MEN1 | |
| SCHEMBL27339270 | 0.81 | CSNK2A1 (0.54) | CXCR4DRD4KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131288-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-12 | — | — | EP | disclosed |
| US-6166015-A | Pyrrolidine derivatives-CCR-3 receptor antagonists | SYNTEX (U.S.A.) INC. (US) | 2000-12-26 | — | — | US | disclosed |
| WO-2000031032-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-02 | — | — | WO | disclosed |