Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10963570 | 0.84 | SLC6A3 (0.43) | SLC6A3FPR2PROKR1MEN1KMT2A | |
| SCHEMBL7956279 | 0.81 | SLC6A3 (0.58) | SLC6A3CHRM2CHRM1CHRM4CHRM3 | |
| SCHEMBL7512949 | 0.81 | SLC6A3 (0.58) | SLC6A3CHRM2CHRM1CHRM4CHRM3 | |
| SCHEMBL961019 | 0.81 | SLC6A3 (0.57) | SLC6A3CHRM2CHRM1CHRM4CHRM3 | |
| SCHEMBL4246228 | 0.81 | CHRM2 (0.60) | SLC6A3CHRM2CHRM1CHRM4CHRM3 | |
| SCHEMBL7236223 | 0.80 | SLC6A3 (0.59) | SLC6A3CHRM2CHRM1CHRM4CHRM3 | |
| SCHEMBL7840990 | 0.80 | SLC6A3 (0.56) | SLC6A3ALDH1A1GAASMN1; SMN2NPC1 | |
| SCHEMBL959762 | 0.79 | SLC6A3 (0.58) | SLC6A3CHRM2CHRM1CHRM4CHRM3 | |
| SCHEMBL13124077 | 0.79 | SLC6A3 (0.58) | SLC6A3CHRM2CHRM1CHRM4CHRM3 | |
| SCHEMBL17892330 | 0.79 | SLC6A3 (0.55) | SLC6A3CHRM2CHRM1CHRM4CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513533-B1 | Heterocyclic substituted phenylacetic-acid derivatives, process for their preparation and their pharmaceutical application | BAYER AG (DE) | 2001-11-21 | — | — | EP | disclosed |
| EP-1127880-A2 | Phenylacetic acid derivatives substituted by a heterocycle and their use as A-II antagonists and as inhibitors of smooth muscle cell proliferation | BAYER AG (DE) | 2001-08-29 | — | — | EP | disclosed |
| US-5776964-A | HYPOTENSIVE AGENTS; ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-07-07 | — | — | US | disclosed |
| US-5521206-A | HYPOTENSIVE AGENTS, TREATMENT OF ATHEROSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-05-28 | — | — | US | disclosed |
| CN-1031339-C | Heterocyclically substituted phenylacetic acid derivatives, processes for their preparation and their use in medicaments | BAYER AG (DE) | 1996-03-20 | — | — | CN | disclosed |
| EP-0513533-A2 | Heterocyclic substituted phenylacetic-acid derivatives, process for their preparation and their pharmaceutical application | BAYER AG (DE) | 1992-11-19 | — | — | EP | disclosed |
| CN-1066065-A | The phenylacetic acid derivatives of heterocyclic substituted and method for making thereof and pharmaceutical use | BAYER AG (DE) | 1992-11-11 | — | — | CN | disclosed |