Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2C | Q5R387 | 2/20 | 0.63 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.59 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.56 |
| ▸ | FAAH | O00519 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.50 |
| ▸ | CPT2 | P23786 | 1/20 | 0.49 |
| ▸ | CPT1A | P50416 | 1/20 | 0.49 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7632257 | 0.89 | DNM1 (0.64) | PLA2G2CDNM1PLA2G10FAAHMEN1 | |
| SCHEMBL28467343 | 0.89 | DNM1 (0.64) | PLA2G2CDNM1PLA2G10FAAHMEN1 | |
| SCHEMBL30679514 | 0.89 | PLA2G2C (0.77) | PLA2G2CDNM1PLA2G10FAAHMEN1 | |
| SCHEMBL31364557 | 0.89 | PLA2G2C (0.77) | PLA2G2CDNM1PLA2G10FAAHMEN1 | |
| SCHEMBL27536177 | 0.89 | PLA2G2C (0.77) | PLA2G2CDNM1PLA2G10FAAHMEN1 | |
| SCHEMBL25067268 | 0.89 | PLA2G2C (0.77) | PLA2G2CDNM1PLA2G10FAAHMEN1 | |
| SCHEMBL31318140 | 0.89 | PLA2G2C (0.77) | PLA2G2CDNM1PLA2G10FAAHMEN1 | |
| SCHEMBL27753924 | 0.89 | PLA2G2C (0.77) | PLA2G2CDNM1PLA2G10FAAHMEN1 | |
| SCHEMBL2482500 | 0.89 | PLA2G2C (0.77) | PLA2G2CDNM1PLA2G10FAAHMEN1 | |
| SCHEMBL117785 | 0.89 | DNM1 (0.64) | PLA2G2CDNM1PLA2G10FAAHMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |