Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 11/20 | 0.55 |
| ▸ | FEN1 | P39748 | 11/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.52 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CPT2 | P23786 | 1/20 | 0.40 |
| ▸ | CPT1A | P50416 | 1/20 | 0.40 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7826615 | 0.88 | ERCC5 (0.48) | ERCC5FEN1PTPN1RNASEH1NR4A2 | |
| SCHEMBL7830115 | 0.86 | NR4A2 (0.47) | ERCC5FEN1PTPN1RNASEH1NR4A2 | |
| SCHEMBL7828114 | 0.83 | ERCC5 (0.49) | ERCC5FEN1PTPN1RNASEH1MEN1 | |
| SCHEMBL7817640 | 0.82 | ERCC5 (0.46) | ERCC5FEN1PTPN1RNASEH1 | |
| SCHEMBL4159497 | 0.79 | PARP10 (0.51) | NR4A2MEN1NPC1KMT2ABRD4 | |
| SCHEMBL7829708 | 0.79 | MAOB (0.51) | NR4A2MEN1NPC1KMT2ABRD4 | |
| SCHEMBL7830529 | 0.75 | ERCC5 (0.59) | ERCC5FEN1PTPN1RNASEH1KMT2A | |
| SCHEMBL7818133 | 0.74 | ERCC5 (0.48) | ERCC5FEN1PTPN1RNASEH1MEN1 | |
| SCHEMBL22777801 | 0.74 | NR4A2 (0.58) | NR4A2MEN1KMT2ANR4A1NR4A3 | |
| SCHEMBL7828353 | 0.74 | ERCC5 (0.57) | ERCC5FEN1PTPN1RNASEH1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086091-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2001-10-10 | — | — | EP | claimed |
| US-6262055-B1 | SULFUR-CONTAINING HETEROARYL DIOXO-BUTYRIC ACID DERIVATIVES | MERCK & CO., INC. | 2001-07-17 | — | — | US | claimed |
| EP-1086091-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2001-03-28 | — | — | EP | claimed |
| WO-1999062897-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1086091-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6262055-B1 | SULFUR-CONTAINING HETEROARYL DIOXO-BUTYRIC ACID DERIVATIVES | MERCK & CO., INC. | 2001-07-17 | — | — | US | disclosed |
| EP-1086091-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999062897-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |