SCHEMBL7828114

SCHEMBL7828114

O=C(O)C(=O)CC(=O)c1ccc(OCc2ccccn2)s1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERCC5 P28715 5/20 0.49
FEN1 P39748 5/20 0.49
RNASEH1 O60930 1/20 0.45
SMN1; SMN2 Q16637 4/20 0.44
NPC1 O15118 4/20 0.44
RAB9A P51151 4/20 0.44
LMNA P02545 1/20 0.44
HPGD P15428 2/20 0.41
PARP10 Q53GL7 1/20 0.41
POLB P06746 1/20 0.39
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 2/20 0.39
PTPN1 P18031 1/20 0.39
ALOX15 P16050 1/20 0.39
HSD17B10 Q99714 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
GAA P10253 1/20 0.39
MAPK14 Q16539 1/20 0.38
SYK P43405 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10366254 0.78 HPGD (0.42) SMN1; SMN2HPGDHSD17B10
SCHEMBL7826615 0.74 ERCC5 (0.48) ERCC5FEN1RNASEH1RAB9ALMNA
SCHEMBL7830115 0.73 NR4A2 (0.47) ERCC5FEN1RNASEH1PARP10PTPN1
SCHEMBL7817640 0.72 ERCC5 (0.46) ERCC5FEN1RNASEH1PTPN1
SCHEMBL7077348 0.69 AGTR1 (0.47) SMN1; SMN2RAB9ALMNAKDM4EALDH1A1
SCHEMBL3881248 0.66 PTPRA (0.53) SMN1; SMN2NPC1RAB9ALMNAPOLB
SCHEMBL7826582 0.66 FEN1 (0.57) ERCC5FEN1RNASEH1POLBPTPN1
Hydrochloric Acid SCHEMBL5304444 0.65 RAB9A (0.51) SMN1; SMN2NPC1RAB9ALMNAPOLB
SCHEMBL11377704 0.65 SMN1; SMN2 (0.66) SMN1; SMN2NPC1RAB9ALMNAHPGD
SCHEMBL7830529 0.64 ERCC5 (0.59) ERCC5FEN1RNASEH1POLBPTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1086091-A4 HIV INTEGRASE INHIBITORS MERCK & CO INC (US) 2001-10-10 EP claimed
US-6262055-B1 SULFUR-CONTAINING HETEROARYL DIOXO-BUTYRIC ACID DERIVATIVES MERCK & CO., INC. 2001-07-17 US claimed
EP-1086091-A1 HIV INTEGRASE INHIBITORS Merck & Co., Inc. (a New Jersey corp.) (US) 2001-03-28 EP claimed
WO-1999062897-A1 HIV INTEGRASE INHIBITORS MERCK & CO., INC. (US) 1999-12-09 WO claimed
EP-1086091-A4 HIV INTEGRASE INHIBITORS MERCK & CO INC (US) 2001-10-10 EP disclosed
US-6262055-B1 SULFUR-CONTAINING HETEROARYL DIOXO-BUTYRIC ACID DERIVATIVES MERCK & CO., INC. 2001-07-17 US disclosed
EP-1086091-A1 HIV INTEGRASE INHIBITORS Merck & Co., Inc. (a New Jersey corp.) (US) 2001-03-28 EP disclosed
WO-1999062897-A1 HIV INTEGRASE INHIBITORS MERCK & CO., INC. (US) 1999-12-09 WO disclosed