Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.62 |
| ▸ | RAB9A | P51151 | 7/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28133947 | 0.84 | KCNK3 (0.67) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL4141992 | 0.84 | KMT2A (0.75) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL30786728 | 0.84 | KMT2A (0.75) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL29627549 | 0.82 | KMT2A (0.73) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL16149341 | 0.81 | NPC1 (0.74) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5465598 | 0.80 | RAB9A (0.64) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL7165213 | 0.79 | RAB9A (0.70) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL16148074 | 0.77 | NPC1 (0.69) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL14372468 | 0.77 | CA12 (0.61) | — | |
| SCHEMBL5466911 | 0.76 | ALDH1A1 (0.64) | NPC1RAB9AKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166015-A | Pyrrolidine derivatives-CCR-3 receptor antagonists | SYNTEX (U.S.A.) INC. (US) | 2000-12-26 | — | — | US | claimed |
| CN-1158256-C | Pyrrolidine derivatives-CCR-3 receptor antagonists | - | 2004-07-21 | — | — | CN | disclosed |
| CN-1331677-A | Pyrrolidine derivatives-CCR-3 receptor antagonists | HOFFMANN LA ROCHE (CH) | 2002-01-16 | — | — | CN | disclosed |
| EP-1131288-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-12 | — | — | EP | disclosed |
| US-6166015-A | Pyrrolidine derivatives-CCR-3 receptor antagonists | SYNTEX (U.S.A.) INC. (US) | 2000-12-26 | — | — | US | disclosed |
| WO-2000031032-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-02 | — | — | WO | disclosed |