Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832246 | 0.89 | ALDH1A1 (0.42) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL2643078 | 0.83 | CYP3A4 (0.49) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL2646699 | 0.83 | KDR (0.54) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL2643461 | 0.82 | IDO1 (0.40) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL2646102 | 0.80 | GABRA1 (0.52) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL2656192 | 0.80 | IDO1 (0.49) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL2643844 | 0.78 | GRM5 (0.53) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL2647252 | 0.78 | FGFR1 (0.62) | ALDH1A1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL20510883 | 0.77 | FGFR1 (0.58) | IDO1CYP3A4HTTFGFR1 | |
| SCHEMBL7819811 | 0.76 | FGFR1 (0.41) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1164134-A1 | Benzimidazole compounds and their use as modulators of the GABA A receptor complex | NEUROSEARCH A/S (DK) | 2001-12-19 | — | — | EP | claimed |
| US-5922724-A | Benzimidazole compounds and their use as modulators of the GABA a receptor complex | NEUROSEARCH A/S (DK) | 1999-07-13 | — | — | US | claimed |
| EP-1164134-A1 | Benzimidazole compounds and their use as modulators of the GABA A receptor complex | NEUROSEARCH A/S (DK) | 2001-12-19 | — | — | EP | disclosed |
| US-5922724-A | Benzimidazole compounds and their use as modulators of the GABA a receptor complex | NEUROSEARCH A/S (DK) | 1999-07-13 | — | — | US | disclosed |