Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.52 |
| ▸ | LTA4H | P09960 | 6/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831291 | 0.92 | MAPT (0.60) | MAPTSIRT2TRPM8LTA4HPLA2G2A | |
| SCHEMBL7817351 | 0.84 | SMN1; SMN2 (0.57) | MAPTTRPM8LTA4HPLA2G2APOLB | |
| SCHEMBL7825305 | 0.83 | MAPT (0.76) | MAPTKDM4EAIMP2MEN1KMT2A | |
| SCHEMBL7824563 | 0.80 | MAPT (0.69) | MAPTKDM4EAIMP2MEN1KMT2A | |
| SCHEMBL7824584 | 0.79 | MAPT (0.80) | MAPTAIMP2 | |
| SCHEMBL7828882 | 0.79 | LTA4H (0.57) | MAPTSIRT2TRPM8LTA4HPLA2G2A | |
| SCHEMBL7837183 | 0.78 | MAPT (0.82) | MAPTPOLBAIMP2MEN1KMT2A | |
| SCHEMBL7834305 | 0.78 | MAPT (1.00) | MAPTKDM4EAIMP2MEN1KMT2A | |
| SCHEMBL7825693 | 0.77 | MAPT (0.66) | MAPTPOLBKDM4EMEN1KMT2A | |
| SCHEMBL7816819 | 0.76 | MAPT (0.62) | MAPTKDM4EAIMP2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861248-B1 | INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS | AMERICAN HOME PROD (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-0861248-A1 | INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-02 | — | — | EP | disclosed |
| US-5750724-A | SEROTONIN 5-HT REUPTAKE INHIBITORS; ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| WO-1997017343-A1 | INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-15 | — | — | WO | disclosed |