Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 3/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828880 | 0.92 | MAPT (0.70) | MAPTSIRT2TRPM8LTA4HPLA2G2A | |
| SCHEMBL7825693 | 0.87 | MAPT (0.66) | MAPTMTNR1AMTNR1BALDH1A1FFAR1 | |
| Hydrochloric Acid SCHEMBL7828805 | 0.85 | HTR2A (0.54) | MAPTTRPM8LTA4HPLA2G2AABCG2 | |
| SCHEMBL7825305 | 0.84 | MAPT (0.76) | MAPTMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL7816819 | 0.84 | MAPT (0.62) | MAPTMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL7838049 | 0.84 | MAPT (0.77) | MAPTMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL7838051 | 0.84 | MAPT (0.77) | MAPTMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL7831631 | 0.82 | MAPT (0.61) | MAPTMTNR1AMTNR1BFFAR1BCHE | |
| SCHEMBL7831289 | 0.81 | LTA4H (0.52) | MAPTSIRT2MTNR1AMTNR1BTRPM8 | |
| SCHEMBL7824563 | 0.80 | MAPT (0.69) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861248-B1 | INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS | AMERICAN HOME PROD (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-0861248-A1 | INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-02 | — | — | EP | disclosed |
| US-5750724-A | SEROTONIN 5-HT REUPTAKE INHIBITORS; ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| WO-1997017343-A1 | INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-15 | — | — | WO | disclosed |