SCHEMBL7829040

SCHEMBL7829040

Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)N(C(C)C)C(C)C)cc3c2CCN)c1

nearest known ligand 0.64

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
GNRHR P30968 7/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8184086 0.88 GNRHR (0.66) GNRHR
SCHEMBL6982851 0.81 KDM4E (0.55) GNRHR
SCHEMBL7912408 0.77 CYP1A2 (0.66) GNRHR
SCHEMBL8030149 0.76 GNRHR (0.55) GNRHR
SCHEMBL8344835 0.75 GNRHR (0.63) GNRHR
SCHEMBL8695357 0.75 HTR1D (0.44) GNRHR
SCHEMBL8596661 0.74 HTR1F (0.42)
SCHEMBL8397440 0.74 GNRHR (0.51) GNRHR
SCHEMBL8689635 0.74 PPARG (0.43)
SCHEMBL8176808 0.74 GNRHR (0.59) GNRHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0986385-A4 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO INC (US) 2001-05-16 EP disclosed
EP-1011667-A4 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO INC (US) 2001-03-28 EP disclosed
EP-0986557-A4 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO INC (US) 2001-03-14 EP disclosed
US-6156772-A INDOLE HORMONE INHIBITORS MERCK & CO., INC. (US) 2000-12-05 US disclosed
EP-1011667-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE Merck & Co., Inc. (a New Jersey corp.) (US) 2000-06-28 EP disclosed
US-6077858-A ADMINISTERING A SUBSTITUTED INDOLE COMPOUND TO THE PATIENTS FOR THE TREATMENT OF A VARIETY OF SEX-HORMONE RELATED AND OTHER CONDITIONS IN BOTH MEN AND WOMEN MERCK & CO., INC. (US) 2000-06-20 US disclosed
EP-0986557-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE Merck & Co., Inc. (US) 2000-03-22 EP disclosed
EP-0986550-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE Merck & Co., Inc. (US) 2000-03-22 EP disclosed
EP-0986385-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO. INC. (US) 2000-03-22 EP disclosed
US-6004984-A Antagonists of gonadotropin releasing hormone MERCK & CO., INC. (US) 1999-12-21 US disclosed
US-5985901-A TREATMENT OF A VARIETY OF SEX-HORMONE RELATED AND OTHER CONDITIONS IN BOTH MEN AND WOMEN MERCK & CO., INC. (US) 1999-11-16 US disclosed
US-5981550-A USEFUL IN TREATING A VARIETY OF SEX-HORMONE RELATED CONDITIONS IN BOTH MEN AND WOMEN, INCLUDING ENDOMETRIOSIS, UTERINE FIBROIDS, POLYCYSTIC OVARIAN DISEASE, HIRSUTISM, PRECOCIOUS PUBERTY, GONADAL STEROID-DEPENDENT NEOPLASIAS MERCK & CO., INC. (US) 1999-11-09 US disclosed
WO-1998055479-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO., INC. (US) 1998-12-10 WO disclosed
WO-1998055470-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO., INC. (US) 1998-12-10 WO disclosed
WO-1998055119-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO., INC. (US) 1998-12-10 WO disclosed
WO-1998055116-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO., INC. (US) 1998-12-10 WO disclosed
US-5756507-A TREATING SEX HORMONE RELATED DISORDERS MERCK & CO., INC. (US) 1998-05-26 US disclosed