Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.58 |
| ▸ | CDK2 | P24941 | 9/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833824 | 0.92 | GSK3B (0.55) | GSK3BCDK2CCNE1KDM4ETDP1 | |
| SCHEMBL7834658 | 0.90 | GSK3B (0.67) | GSK3BCDK2CCNE1KDM4EALDH1A1 | |
| SCHEMBL7831991 | 0.89 | GSK3B (0.50) | GSK3BCDK2KDM4ETDP1ALDH1A1 | |
| SCHEMBL7833111 | 0.87 | GSK3B (0.48) | GSK3BKDM4EALDH1A1GAAHPGD | |
| SCHEMBL7832694 | 0.84 | GSK3B (0.50) | GSK3BCDK2KDM4ETDP1ALDH1A1 | |
| SCHEMBL7832341 | 0.83 | GSK3B (0.47) | GSK3BKDM4ETDP1ALDH1A1GAA | |
| SCHEMBL7833604 | 0.81 | CDK2 (0.47) | GSK3BCDK2CCNE1 | |
| SCHEMBL7835008 | 0.80 | GSK3B (0.57) | GSK3BCDK2CCNE1 | |
| SCHEMBL7832356 | 0.77 | CDK2 (0.47) | GSK3BCDK2CCNE1 | |
| SCHEMBL7832777 | 0.77 | GSK3B (0.50) | GSK3BCDK2KDM4ETDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820997-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5985882-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0820997-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-28 | — | — | EP | disclosed |