Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.47 |
| ▸ | GSK3B | P49841 | 5/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835008 | 0.82 | GSK3B (0.57) | CDK2GSK3BCCNE1 | |
| SCHEMBL7833604 | 0.81 | CDK2 (0.47) | CDK2GSK3BCCNE1CHEK1CCNA2 | |
| SCHEMBL7829217 | 0.77 | GSK3B (0.58) | CDK2GSK3BCCNE1 | |
| SCHEMBL8571772 | 0.74 | GSK3B (0.42) | CDK2GSK3BCCNE1 | |
| SCHEMBL7835136 | 0.74 | CDK2 (0.41) | CDK2GSK3BCCNE1 | |
| SCHEMBL7835614 | 0.74 | CDK2 (0.41) | CDK2GSK3BCCNE1 | |
| SCHEMBL7832339 | 0.73 | GSK3B (0.43) | CDK2GSK3BCCNE1 | |
| SCHEMBL7820733 | 0.73 | CDK2 (0.45) | CDK2GSK3BCCNE1 | |
| SCHEMBL12953912 | 0.73 | GSK3B (0.76) | CDK2GSK3BCCNE1 | |
| SCHEMBL7829710 | 0.72 | GSK3B (0.41) | CDK2GSK3BCCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820997-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5985882-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0820997-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-28 | — | — | EP | disclosed |